Cancer is a disease of clonal evolution within the body1–3. This has profound clinical implications for neoplastic progression, cancer prevention and cancer therapy. Although the idea of cancer as an evolutionary problem
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چکیده
| Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells compete for space and resources, evade predation by the immune system and can even cooperate to disperse and colonize new organs. The evolution of neoplastic cells explains both why we get cancer and why it has been so difficult to cure. The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer. R E V I E W S NATURE REVIEWS | CANCER ADVANCE ONLINE PUBLICATION | 1 Nature Reviews Cancer | AOP, published online 16 November 2006; doi:10.1038/nrc2013
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